张吉泉,博士,副教授,硕士研究生导师(学术型)。2015年毕业于中山大学药学院,获理学博士学位。贵州医科大学药物化学学科青年骨干教师,担任贵州省化学合成药物研发利用工程技术研究中心办公室主任,贵阳市天然产物活性成分成药性研究创新团队负责人。
研究方向:1)小分子靶向抗肿瘤药物研究;2)新型抗糖尿病药物研究;3)过渡金属参与的偶联反应研究。近三年,主持国家自然科学基金青年基金(81703356)、贵州省科技支撑计划重点项目(黔科合[2016]支撑2819)、贵州省科技合作计划项目(黔科合LH字[2016]7349)、贵州省卫计委科技基金(gzwjkj2016-1-051)、贵阳市科技创新团队(筑科合[2017]30-28号)等项目8项,累计项目经费110余万元。相继以通讯及第一作者在国际权威期刊Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Organic & Biomolecular Chemistry, New Journal of Chemistry, European Journal of Organic Chemistry等上发表SCI论文7篇;参与申请PCT及中国发明专利17项,授权7项;参与获得贵州省高等学校科学研究优秀成果奖自然科学类三等奖1项(2014年)。指导学生获得贵州医科大学优秀硕士论文一等奖1人(2018年),获贵州医科大学优秀本科毕业论文三等奖1人(2016年)。
联系方式:zjqgmc@163.com
近期发表论文
(1)Jun Cao,Zi-Li Chen, Shu-Min Li, Gao-Feng Zhu, Yuan-Yong Yang, Cong Wang, Wen-Zhang Chen, Jian-Ta Wang,Ji-Quan Zhang*, Lei Tang*.Palladium-catalyzed regioselective C-2 arylation of benzofurans withN'-acyl arylhydrazines.European Journal of Organic Chemistry,2018, 2018(22), 2774-2779.
(2) Ji-Quan Zhang, Shu-Min Li, Xiao Ma, Gang Zhong, Rui Chen, Xiao-Shuang Li, Gao-Feng Zhu, Bo Zhou, Bing Guo, Hao-Shu Wu, Lei Tang*. Discovery of novel tetrahydrocarbazoles with potent hypoglycemic and hypolipemic activities. European Journal of Medicinal Chemistry, 2018, 150, 102-112.
(3) Ji-Quan Zhang*,#, Jun Cao#, Wei Li, Shu-Min Li, Yong-Kang Li, Jian-Ta Wang, Lei Tang*.Palladium/copper-catalyzed arylation of alkenes withN′-acyl arylhydrazines. New Journal of Chemistry, 2017, 41, 437-441.
(4) Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Hui-Xuan Chen, Yu Luo, Zheng-Chao Tu, Jiang Weng, Gui Lu*. Design, synthesis and biological evaluation of substituted pyrimidines as potential PI3K inhibitors. Journal of Medicinal Chemistry, 2016, 59, 7268-7274.
(5) Ji-Quan Zhang, Yan-Shi Xiong, Albert S. C. Chan, Gui Lu*. Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N’-acyl arylhydrazines and phosphites. RSC. Advances, 2016, 6, 84587-84591.
(6) Ji-Quan Zhang, Gong-Bin Huang, Jiang Weng, Gui Lu*, Albert S. C. Chan. Copper(II)-catalyzed coupling reaction: an efficient and regioselective approach to N’,N’-diaryl acylhydrazines. Organic & Biomolecular Chemistry, 2015, 13, 2055-2063.
(7) Ji-Quan Zhang, Jian-Ta Wang, Hao-Shu Wu, Yao-Yao He, Gao-Feng Zhu, Xing Cui, Lei Tang*. Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivative.Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3324-3327.
代表性专利:
(1)张吉泉,曹俊,王丽丽,汤磊,李述敏.一种新的五元芳杂环和芳环并五元芳杂环芳基化合成方法.中国专利,2018, CN201810000789.9
(2)张吉泉,李述敏,徐晓倩,武婷婷,汤磊. PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用.中国专利,2018, CN201810022227.4.
(3)张吉泉,汤磊,杜克斯,陈瑞,李维,吴昊姝,陈瑞.齐墩果酸衍生物及其药物组合物在药物中的应用.中国专利,2016, CN105998032.
(4)Jian-Cun Zhang, Ying-Jun Zhang, Wei-Hong Zhang, Bing Liu,Ji-Quan Zhang, Jin-Lei Liu, Lu Zhang. Aminoquinazoline derivatives and their salts and methods for use.2013. 05. 23,WO2013071697A1(PCT专利)