严雪龙,博士,副教授,青年博士生导师。
研究方向
生药学、天然药物化学
药食两用中药产品研发
联系方式:
电话15250968467
电子邮件:yanxlong54@163.com
简介
主要研究方向为药用植物活性天然产物的挖掘、结构修饰、药效与作用机制、药食两用产品研发。2009-2016在中国药科大学中药学院本硕连读,分别获中药学学士及中药资源学硕士学位。2020年6月毕业于中山大学药学院,获生药学专业博士学位。2020年7月-2022年9月在贵州医科大学基础医学博士后科研流动站开展博士后研究,2020年9月出站后留校工作。迄今,在Journal of the American Chemical Society、Acta Pharmaceutica Sinica B、Journal of Medicinal Chemistry、Organic Letters、Bioorganic Chemistry等国际期刊上发表通讯及第一作者论文14篇。
经历
2020/10—至今贵州医科大学药学院,副教授,青年博士生导师
2020/08—2022/09贵州医科大学基础医学博士后科研流动站,博士后研究员
2016/09—2020/06中山大学药学院,生药学、博士
2013/09—2016/07中国药科大学,中药资源学,硕士
2009/09—2013/07中国药科大学,中药学,学士
教学情况
1.生药学
2.中药鉴定学
3.药用植物学
科研项目
1.国家自然科学基金,22167009:抗肥胖症瑞香烷型二萜小分子探针的构建及其靶点识别,35万元,主持,2022. 01-2025. 12。
2.中国博士后科学基金,2021M693809:中药黄芫花中抗肥胖症瑞香烷型二萜的发现、结构修饰及构效关系研究,8万元,主持,已结题。
3.贵州省科技厅基础研究计划重点项目,黔科合基础-ZK[2024]重点037:基于importin-b1为靶点抗去势抵抗性前列腺癌瑞香烷型二萜先导物的发现、构效关系及初步成药性研究,30万元,主持,2024.04~2028-04。
论著专利
(1)Xue-Long Yan,Yue-Hua Pan,Run-Zhu Fan,Qin-Qin Song, Shen Li, Jia-Luo Huang, Wei Li, Dong Huang, Fang-Yu Yuan, Gui-Hua Tang, Yong Rao,*Zhi-Shu Huang, and Sheng Yin*.Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent.Journal of Medicinal Chemistry, 2023, 66, 5839−5858.(中科院1区top, IF 8.039).
(2)Xue-Long Yan, Jun Sang, Shi-Xin Chen, Wei Li, Gui-Hua Tang, Li-She Gan, and Sheng Yin*. Euphorkanlide A, a Highly Modifified Ingenane Diterpenoid with a C24
Appendage from Euphorbia kansuensis.Organic Letters, 2019, 21, 4128−4131.(中科院1区top, IF 6.072)
(3) Jia-Luo Huang,#Xue-Long Yan,#Wei Li, Run-Zhu Fan, Shen Li, Jianghe Chen, Zhenhua Zhang, Jun Sang, Lu Gan, Gui-Hua Tang, Hongwu Chen, Junjian Wang,*and Sheng Yin*,Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer.Journal of the American Chemical Society, 2022,144, 17522−17532. (共同一作,中科院1区Top,IF 16.383)
(4) Jia-Luo Huang,#Xue-Long Yan,#Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang,* Sheng Yin*.Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer.Acta Pharmaceutica Sinica B, 2023,13(12), 4934-4944.(共同一作,中科院1区Top,IF 14.5)
(5)Shen Li, Lu Gan, Yi-Jing Tian, Yang Tian, Run-Zhu Fan, Dong Huang, Fang-Yu Yuan, Xu Zhang, Yan Lin, Qin-Feng Zhu, Gui-Hua Tang,Xue-Long Yan,*Sheng Yin*. Presegetane diterpenoids fromEuphorbia sieboldianaas a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.Bioorganic Chemistry, 2021, 114, 105222. (中科院1区,IF 5.307)
(6)Xue-Long Yan, Jun-Sheng Zhang, Jia-Luo Huang, Yao Zhang, Jia-Qi Chen, Gui-Hua Tang, Sheng Yin*. Euphonoids A−G, cytotoxic diterpenoids from Euphorbia fischeriana. Phytochemistry, 2019, 166, 112064.(中科院2区, IF 4.004).
(7)Xue-Long Yan, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Shang-Gao Liao*. Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis.Arabian Journal of Chemistry,2022, 15, 103807.(中科院2区,IF 6.212)
(8)Xue-Long Yan, Ming-Feng Zou, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*, Shang-Gao Liao*.Euphorane C, an unusual C17-norabietane diterpenoid from Euphorbia dracunculoides induces cell cycle arrest and apoptosis in human leukemia K562 cells.Arabian Journal of Chemistry, 2022, 15, 104203.(中科院2区,IF 6.212).
(9)Xue-Long Yan, Jun-Sang, Xu Zhang, Yan Lin, Qing-De Long, Qin-Feng Zhu, Shang-Gao Liao*. Euphorboside A, a cytotoxic meroterpenoid glycoside with an unusual humulene-phloroglucinol skeleton from Euphorbia kansuensis.Fitoterapia, 2021, 153,104966.(中科院3区,IF 3.204).
(10) Bei-Ling Chen, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*,Xue-Long Yan*. An unusual indole-diterpenoid with C-17 norcassane skeleton from Euphorbia fischeriana induces HEL cell cycle arrest and apoptosis.Fitoterapia, 2022, 159, 105195.(中科院3区,IF 3.204).